728x90 반응형 Main/Neuroscience8 Binding Affinity(결합친화도) vs Receptor Occupancy (수용체 점유율) Binding Affinity와 Receptor Occupancy: 약물과 수용체의 상호작용 이해하기약물과 수용체의 상호작용은 신약 개발과 약리학에서 매우 중요한 주제입니다. 그중에서도 **Binding Affinity(결합 친화도)**와 **Receptor Occupancy(수용체 점유율)**는 약물의 효능과 작용을 이해하는 데 핵심적인 두 가지 개념입니다.하지만 이 둘은 각각 다른 측면을 강조합니다. 이번 글에서는 Binding Affinity와 Receptor Occupancy의 정의, 차이점, 그리고 약물 설계와 임상에서의 활용법을 쉽게 풀어보겠습니다.1. Binding Affinity (결합 친화도): 약물과 수용체의 결합 강도Binding Affinity는 약물이 수용체에 얼마나 강하게 결합하.. 2025. 1. 13. [Neuroscience] Semantic and Episodic Memory #1 The human hippocampus The hippocampus("seahorse") was given its name by Bolognese anatomist Giulio Cesare Aranzi (circa 1564) ++we talked about this in the vision lecture, "Jennifer Aniston Cell" -respond to Sydney opera house… Hippocampus & Memory Modern studies of the hippocampal role in memory began with studies of the famous neurological patient H.M. Large portions of H.M.'s medial temporal .. 2023. 4. 12. Neurobiology of Fear #4 Neurobiology of Anxiety disorders Cued and contextual fear conditioning are used as animal models for studying the neurobiological basis for human disorders such as: Understanding the neural circuits that drive fear and anxiety may allow us to develop new treatments for these disorders We would like to know: how can fear be inhibited or suppressed? ++ understanding these behaviors are very impor.. 2023. 4. 12. Neurobiology of Fear #3 Three types of optogenetic transgenes Channelrhodopsin is a sodium channel sensitive to blue light, which causes sodium to enter and depolarize the cell. (excites cell) Halorhodopsin is a chloride pump sensitive to yellow light, which causes chloride to be pumped in, hyperpolarizing the cell. (inhibit cell) Archaerhodopsin is a proton pump sensitive to green light, which causes hydrogen ions (pr.. 2023. 4. 12. Neurobiology of Fear #2 Anatomy of the Amygdala The "striatal amygdala" has inhibitory projection neurons, and consists of the central (Ce) and medial (M) nuclei. The central and medial nucleus together are sometimes referred to as the "extended amygdala" The "cortical amygdala" has excitatory projection neurons, and consists of the Lateral (LA), Basal (B) and accessory basal (AB) nuclei. The lateral and basal nucleus .. 2023. 4. 12. Neurobiology of Fear #1 Expression of defensive behaviors varies with intensity of danger Predators consuming prey go through procurement, pursuit and strike Prey have adapted to these predator behaviors with anxiety, fear and panic-related behaviors (increasing intensity of danger) ++ anxiety and fear related behaviors our kinds of expressions of defensive behavior of animals have when they are facing danger and threa.. 2023. 4. 12. 이전 1 2 다음 728x90 반응형